Andy Carter fled his native Omaha when his marriage fell apart, but not before he humiliated himself by ruining his brother-in-law’s wedding reception (becoming the subject of a viral video in the process), and lost his job with an insurance company when he suffered an emotional meltdown. Living in a fourth-floor walk-up in New York City, Andy has been adopted by a straw cat named Jasper who eats cereal and presents him with dead mice. Working as a bartender, Andy is drinking too much to numb the pain of having been left by his ex-wife, Karen, for the handsome paramedic who moved in down the street.
It seems that things couldn’t get any worse. Until they do. Andy’s mother, Nancy, asks him to come home to say good-bye to his dying grandfather. When he arrives in Omaha, he finds that much remains the same, but also confronts major changes. His ex-wife is living with the paramedic in their former home, and his mother’s career as a right-wing talk-radio-host is taking off thanks, in part, to her recent startling makeover, but her hostility toward marriage equality has made his parents’ home the target of vandalism comprised of copious amounts of glitter, Ken dolls, and blow-up dolls.
And then after visiting his grandfather in a hospice facility, Andy encounters Daisy, a mysterious young woman with fifteen tattoos, no job, and plenty of attitude who claims she will help Andy learn to be happy again.